My friends at Tinybop have released their first app, The Human Body, in which “curious kids ages 4+ can see what we’re made of and how we work, from the beating heart to gurgling guts”. Kelli Anderson did the illustrations for the app and they look amazing. Can’t wait to try this out with Ollie and Minna.
If you’re at all interested in the Pioneer Anomaly (and you really should be, it’s fascinating), The Pioneer Detectives ebook by Konstantin Kakaes looks interesting.
Explore one of the greatest scientific mysteries of our time, the Pioneer Anomaly: in the 1980s, NASA scientists detected an unknown force acting on the spacecraft Pioneer 10, the first man-made object to journey through the asteroid belt and study Jupiter, eventually leaving the solar system. No one seemed able to agree on a cause. (Dark matter? Tensor-vector-scalar gravity? Collisions with gravitons?) What did seem clear to those who became obsessed with it was that the Pioneer Anomaly had the potential to upend Einstein and Newton — to change everything we know about the universe.
Kakaes was a science writer for The Economist and studied physics at Harvard, so this topic seems right up his alley. Available for $2.99 for the Kindle and for iBooks on iOS.
The show builds on many of themes in the innovation history trilogy of The Ghost Map, The Invention Of Air, and Where Good Ideas Come From, but is based on new material with a completely different structure. Each hour-long episode takes one facet of modern life that we mostly take for granted — artificial cold, clean drinking water, the lenses in your spectacles — and tells the 500-year story of how that innovation came into being: the hobbyists and amateurs and entrepreneurs and collaborative networks that collectively made the modern world possible. It’s also the story of the unintended consequences of these inventions: air conditioning and refrigeration didn’t just make it possible to build ski slopes in the desert; they also triggered arguably the largest migration of human beings in the history of the species — to cities like Dubai or Phoenix that would otherwise be virtually uninhabitable.
Outside of the nature documentaries like Planet Earth, I haven’t seen a decent science series on TV in a long while — most of them are too slow with too much filler and not enough actual, you know, science — so I’m not getting my hopes up too high, but hoping this one bucks that trend.
Hey there. Sleeping ok? Perhaps not after you watch this microscopic video of a mosquito’s mouthparts searching the flesh of its victim for blood vessels.
I’ve never been shy about killing mosquitos but now I am on a mission.
On January 15, 1919 in Boston’s North End, a storage container holding around 2.3 million gallons of molasses ruptured, sending a 8-15 ft. wave of molasses shooting out into the streets at 35 mph. Twenty-one people died, many more were injured, and the property damage was severe. In an article in Scientific American, Ferris Jabr explains the science of the molasses flood, including why it was so deadly and destructive.
A wave of molasses does not behave like a wave of water. Molasses is a non-Newtonian fluid, which means that its viscosity depends on the forces applied to it, as measured by shear rate. Consider non-Newtonian fluids such as toothpaste, ketchup and whipped cream. In a stationary bottle, these fluids are thick and goopy and do not shift much if you tilt the container this way and that. When you squeeze or smack the bottle, however, applying stress and increasing the shear rate, the fluids suddenly flow. Because of this physical property, a wave of molasses is even more devastating than a typical tsunami. In 1919 the dense wall of syrup surging from its collapsed tank initially moved fast enough to sweep people up and demolish buildings, only to settle into a more gelatinous state that kept people trapped.
This could just be a Boston urban legend, but it’s said that on hot days in the North End, the sweet smell of molasses can be detected wafting through the air.
This is what the trees look like near Chernobyl when you cut them down. It’s a biiiit tricky but see if you can spot when the nuclear plant disaster happened…
Mean growth rate was severely depressed and more variable in 1987-1989 and several other subsequent years, following the nuclear accident in April 1986 compared to the situation before 1986. The higher frequency of years with poor growth after 1986 was not caused by elevated temperature, drought or their interactions with background radiation. Elevated temperatures suppressed individual growth rates in particular years. Finally, the negative effects of radioactive contaminants were particularly pronounced in smaller trees. These findings suggest that radiation has suppressed growth rates of pines in Chernobyl, and that radiation interacts with other environmental factors and phenotypic traits of plants to influence their growth trajectories in complex ways.
These caterpillars in the Amazon rain forest travel together in kind of a treadmill formation, with the whole group able to travel faster than any individual caterpillar.
Been waiting for this one for awhile: a three-minute trailer for Cosmos: A Spacetime Odyssey, a sequel to Carl Sagan’s Cosmos.
The show will be hosted by Neil deGrasse Tyson and is being produced by Seth MacFarlane (Family Guy) and Sagan’s widow Ann Druyan. If MacFarlane’s involvement raises some eyebrows, it shouldn’t: he came up with the idea of rebooting the series and is apparently a big space nerd and fan of the original series. (via devour)
Pitch is an extremely viscous substance, about 2 million times more viscous than honey. Drops take 7-13 years to form and less than a second to fall. A similar experiment has been running at University of Queensland in Brisbane, Australia since 1927…their next drop is expected to fall sometime later this year.
From The New Yorker: Jenny McCarthy’s Dangerous Views. She’s been hired as a new host on The View. Some worry that we’ll be hearing a lot more about her anti-vaccine postions. Of course, if you are making life-decisions based on the views of people on The View, you might want to consider the host who thought the world might be flat.
Or rather, protozoan? Toxoplasma gondii is a protozoan parasite which is transmitted from rodents to cats through a crafty mechanism…it makes mice attracted to the smell of cat urine. Mouse goes near cat, cat eats mouse, T. gondii has a new host. From cats, the parasite can jump into humans, where it may be responsible for all sorts of nastiness:
Well, the behavioral influence plays out in a number of strange ways. Toxoplasma infection in humans has been associated with everything from slowed reaction times to a fondness toward cat urine — to more extreme behaviors such as depression and even schizophrenia. And here’s the kicker: Two different research groups have independently shown that Toxo-infected individuals are three to four times as likely of being killed in car accidents due to reckless driving.
And maybe makes us want to invent networking technology and share cool links? In this five-minute talk, Kevin Slavin cleverly connects viral media with T. gondii:
That video was so good, I watched the whole thing twice.
Using pulse monitors attached to the singers’ ears, the researchers measured the changes in the choir members’ heart rates as they navigated the intricate harmonies of a Swedish hymn. When the choir began to sing, their heart rates slowed down.
“When you sing the phrases, it is a form of guided breathing,” says musicologist Bjorn Vickhoff of the Sahlgrenska Academy who led the project. “You exhale on the phrases and breathe in between the phrases. When you exhale, the heart slows down.”
But what really struck him was that it took almost no time at all for the singers’ heart rates to become synchronized. The readout from the pulse monitors starts as a jumble of jagged lines, but quickly becomes a series of uniform peaks. The heart rates fall into a shared rhythm guided by the song’s tempo.
Did you know that there are new human beings? Like, not just new human babies but new species of humans? And not just new species of humans, but new species of humans who lived at the same time as, and even possibly bred with, modern humans, aka us? (Helloooooo, mesofacts.)
If you’ve read kottke.org over the years, you’ve likely heard of Homo floresiensis (aka Flores man, aka Hobbits), a species whose remains were discovered in present-day Indonesia in 2003. Homo floresiensis lived 95,000 to 13,000 years ago and stood about three feet high.
In this month’s National Geographic, Jamie Shreeve tells the story of the 2010 discovery of the Denisovans, hominids who lived in modern-day Russia as late as 40,000 years ago. Only a handful of bone fragments and teeth have been recovered, but DNA and other evidence suggests that Denisovans, Neanderthals, and modern humans lived together in the same place and interbred.
By the time of the Denisova symposium, Pääbo and his colleagues had published first drafts of the entire Neanderthal and Denisovan genomes. Reading so many more pages allowed Pääbo and his colleagues, including David Reich at Harvard University and Montgomery Slatkin at the University of California, Berkeley, to discover that human genomes today actually contain a small but significant amount of Neanderthal code — on average about 2.5 percent. The Neanderthals still may have been swept into extinction by the strange, high-browed new people who followed them out of Africa, but not before some commingling that left a little Neanderthal in most of us, 50,000 years later. Only one group of modern humans escaped that influence: Africans, because the commingling happened outside that continent.
Although the Denisovans’ genome showed that they were more closely related to the Neanderthals, they too had left their mark on us. But the geographic pattern of that legacy was odd. When the researchers compared the Denisovan genome with those of various modern human populations, they found no trace of it in Russia or nearby China, or anywhere else, for that matter — except in the genomes of New Guineans, other people from islands in Melanesia, and Australian Aborigines. On average their genomes are about 5 percent Denisovan. Negritos in the Philippines have as much as 2.5 percent.
The Red Deer Cave dwellers’ unusual features included a flat face, a broad nose, a jutting jaw that lacked a chin, large molar teeth, a rounded braincase with prominent brow ridges, and thick skull bones, the researchers say.
Their brains were “moderate in size,” Curnoe added.
Despite this seemingly primitive human design, radiocarbon dating of charcoal from the fossil deposits suggests the Red Deer Cave people lived just 14,500 to 11,500 years ago, the team says-a time by which all other human species, such as Neanderthals, are thought to have died out.
As with the other potential new human species, and as is proper in science, there is some skepticism about the Red Deer Cave people.
The team’s suggestion that the Red Deer Cave people are somehow evolutionarily unique is receiving a skeptical reception from other scientists.
Physical anthropologist Erik Trinkaus described the findings as “an unfortunate overinterpretation and misinterpretation of robust early modern humans, probably with affinities to modern Melanesians”-indigenous peoples of Pacific islands stretching from New Guinea to Fiji (map).
“There is nothing extraordinary” about the newly announced fossil human, added Trinkaus, of Washington University in St. Louis, via email.
Philipp Gunz, of Max Planck Institute for Evolutionary Anthropology in Germany, isn’t convinced by the study team’s interpretation either.
“I would be surprised if it really was a new human group that was previously undiscovered,” said, Gunz, also a physical anthropologist.
Turning the Sun into a giant radio telescope through gravitational lensing will take some work, but it is possible.
An Italian space scientist, Claudio Maccone, believes that gravitational lensing could be used for something even more extraordinary: searching for radio signals from alien civilizations. Maccone wants to use the sun as a gravitational lens to make an extraordinarily sensitive radio telescope. He did not invent the idea, which he calls FOCAL, but he has studied it more deeply than anyone else. A radio telescope at a gravitational focal point of the sun would be incredibly sensitive. (Unlike an optical lens, a gravitational lens actually has many focal points that lie along a straight line, called a focal line; imagine a line running through an observer, the center of the lens, and the target.) For one particular frequency that has been proposed as a channel for interstellar communication, a telescope would amplify the signal by a factor of 1.3 quadrillion.
The results are as reliable as flipping a light switch, but even after decades of testing, no one knows exactly why it works. Dr. Kaplitt, the surgeon who installed Rebecca Serdans’ implant, explains it by likening the brain to a collection of electrical circuits. A disorder like dystonia is a failure of those circuits. When you install a brain stimulation device, “it’s presumably blocking abnormal information from getting from one part of the brain to another, or normalizing that information.” But Kaplitt is the first to acknowledge that this is just a theory. “The mechanism by which brain stimulation works is still somewhat unclear and controversial.”
But the lingering questions haven’t slowed down research. There are already patents that would use brain stimulation implants to enhance memory or prevent stuttering, to cure anorexia or bring a person to orgasm. Experimental studies use the device to treat Alzheimer’s disease and drug addiction. Those circuits aren’t as well understood as the circuits governing movement disorders, but the principle is no different. Once you’ve got a line into the circuitry of the brain, Parkinson’s is just the beginning.
The center of the Sun is extremely dense, and a photon can only travel a tiny distance before running into another hydrogen nucleus. It gets absorbed by that nucleus and the re-emitted in a random direction. If that direction is back towards the center of the Sun, the photon has lost ground! It will get re-absorbed, and then re-emitted, over and over, trillions of times.
This is from 1997, so that figure might have been revised a bit (anyone have updated numbers?) but still, that’s incredible. (via hacker news)
Andrew Johnson has been diagnosed with Early Onset Parkinson’s Disease and recently underwent deep brain stimulation (DBS) surgery to implant a brain pacemaker that supplies his brain with regular and reliable electrical pulses. In this incredible video, Johnson turns the pacemaker off and you can see the effect that DBS has had on his life.
Understatement of the year at the end of the video. Wow. Johnson writes about his experience with Parkinson’s on his site, Young and Shaky. (thx, eamon)
In analysing the Odyssey, they identified 342 unique characters and over 1700 relations between them.
Having constructed the social network, Miranda and co then examined its structure. “Odyssey’s social network is small world, highly clustered, slightly hierarchical and resilient to random attacks,” they say.
What’s interesting about this conclusion is that these same characteristics all crop up in social networks in the real world. Miranda and co say this is good evidence that the Odyssey is based, at least in part, on a real social network and so must be a mixture of myth and fact.
We’re used to thinking that technology progresses. Stuff gets better. But that’s not the case with concrete…the Romans made concrete that’s superior to the stuff we have now and scientists recently found out why it’s so good.
The secret to Roman concrete lies in its unique mineral formulation and production technique. As the researchers explain in a press release outlining their findings, “The Romans made concrete by mixing lime and volcanic rock. For underwater structures, lime and volcanic ash were mixed to form mortar, and this mortar and volcanic tuff were packed into wooden forms. The seawater instantly triggered a hot chemical reaction. The lime was hydrated — incorporating water molecules into its structure — and reacted with the ash to cement the whole mixture together.”
The Portland cement formula crucially lacks the lyme and volcanic ash mixture. As a result, it doesn’t bind quite as well when compared with the Roman concrete, researchers found. It is this inferior binding property that explains why structures made of Portland cement tend to weaken and crack after a few decades of use, Jackson says.
The case involved Myriad Genetics Inc., which holds patents related to two genes, known as BRCA1 and BRCA2, that can indicate whether a woman has a heightened risk of developing breast cancer or ovarian cancer.
Justice Clarence Thomas, writing for the court, said the genes Myriad isolated are products of nature, which aren’t eligible for patents.
The high court’s ruling was a win for a coalition of cancer patients, medical groups and geneticists who filed a lawsuit in 2009 challenging Myriad’s patents. Thanks to those patents, the Salt Lake City company has been the exclusive U.S. commercial provider of genetic tests for breast cancer and ovarian cancer.
The challengers argued the patents have allowed Myriad to dictate the type and terms of genetic screening available for the diseases, while also dissuading research by other laboratories.
Now, there’s another important implication of genomic ancestry studies: Most of the people you are descended from are no more genetically related to you than strangers are. Or to put it another way, your genealogical family tree, which includes all the history of your family going back thousands of years, is much larger than your genetic family tree-the people whom genome sequencing would pinpoint as related to you. 99.9 percent of your genome is the same as that of every other human being (apart from the x and y chromosomes), and that .1 percent of variation in each person gets thinned out pretty quickly across the generations, as each child gets half of each of her parents’ genomes, passes on half to each of her children, and so on. Geneticist Luke Jostins did a nice mathematical analysis and estimated that you have only about a 12 percent chance of being genetically related to an ancestor 10 generations ago; by the time you get to a 14-generation ancestor, the probability is nearly zero.
A mammoth recently found in Siberia was so well preserved that when researchers were chipping it out of the ice, liquid blood flowed out.
Semyon Grigoriev, chairman of the university’s Museum of Mammoths and head of the expedition, said: “The fragments of muscle tissues, which we’ve found out of the body, have a natural red colour of fresh meat. The reason for such preservation is that the lower part of the body was underlying (sic) in pure ice, and the upper part was found in the middle of tundra. We found a trunk separately from the body, which is the worst-preserved part.”
The temperature was ten degrees celsius below zero when the mammoth was found, so the discovery of liquid blood was a shock. “It can be assumed that the blood of mammoths had some cryo-protective properties,” Grigoriev said. “The blood is very dark, it was found in ice cavities below the belly and when we broke these cavities with a pick, the blood came running out.”
4. Arkansas. Official state bird: northern mockingbird
Christ. What makes this even less funny is that there are like eight other states with mockingbird as their official bird. I’m convinced that the guy whose job it was to report to the state’s legislature on what the official bird should be forgot until the day it was due and he was in line for a breakfast sandwich at Burger King. In a panic he walked outside and selected the first bird he could find, a dirty mockingbird singing its stupid head off on top of a dumpster.
What it should be: painted bunting
More hilarious science journalism, please. Yes, in addition to the excellent What If? (via @jessamyn)
The researchers, at Oregon Health and Science University, took skin cells from a baby with a genetic disease and fused them with donated human eggs to create human embryos that were genetically identical to the 8-month-old. They then extracted stem cells from those embryos.
The embryo-creation technique is essentially the same as that used to create Dolly the sheep and the many cloned animals that have followed. In those cases, the embryos were implanted in the wombs of surrogate mothers.
These embryos won’t work for producing clones humans…they are being used to harvest stem cells.
The Oregon researchers, who published a paper on their work in the journal Cell, say their goal is what has been called therapeutic cloning: making embryonic stem cells that are genetically identical to a particular patient.
Embryonic stem cells can turn into any type of cell in the body, like heart cells, muscles or neurons. That raises the hope that one day the cells will be turned into replacement tissue or even replacement organs to treat a host of diseases.
In this morning’s NY Times, Angelina Jolie writes about her decision to have a preventive double mastectomy to hopefully ward off cancer.
My mother fought cancer for almost a decade and died at 56. She held out long enough to meet the first of her grandchildren and to hold them in her arms. But my other children will never have the chance to know her and experience how loving and gracious she was.
We often speak of “Mommy’s mommy,” and I find myself trying to explain the illness that took her away from us. They have asked if the same could happen to me. I have always told them not to worry, but the truth is I carry a “faulty” gene, BRCA1, which sharply increases my risk of developing breast cancer and ovarian cancer.
It happens that just last night I read about the BRCA-1 gene in Siddhartha Mukhergee’s excellent biography of cancer, The Emperor of All Maladies. This part is right near the end of the book:
Like cancer prevention, cancer screening will also be reinvigorated by the molecular understanding of cancer. Indeed, it has already been. The discovery of the BRCA genes for breast cancer epitomizes the integration of cancer screening and cancer genetics. In the mid-1990s, building on the prior decade’s advances, researchers isolated two related genes, BRCA-1 and BRCA-2, that vastly increase the risk of developing breast cancer. A woman with an inherited mutation in BRCA-1 has a 50 to 80 percent chance of developing breast cancer in her lifetime (the gene also increases the risk for ovarian cancer), about three to five times the normal risk. Today, testing for this gene mutation has been integrated into prevention efforts. Women found positive for a mutation in the two genes are screened more intensively using more sensitive imaging techniques such as breast MRI. Women with BRCA mutations might choose to take the drug tamoxifen to prevent breast cancer, a strategy shown effective in clinical trials. Or, perhaps most radically, women with BRCA mutations might choose a prophylactic mastectomy of both breasts and ovaries before cancer develops, another strategy that dramatically decreases the chances of developing breast cancer.
Radical is an understatement…what a tough and brave decision to make. Again from the book, I liked this woman’s take on it:
An Israeli woman with a BRCA-1 mutation who chose this strategy after developing cancer in one breast told me that at least part of her choice was symbolic. “I am rejecting cancer from my body,” she said. “My breasts had become no more to me than a site for my cancer. They were of no more use to me. They harmed my body, my survival. I went to the surgeon and asked him to remove them.”
Five to 10 percent of breast cancers occur in women with a genetic predisposition for the disease, usually due to mutations in either the BRCA1 or BRCA2 genes. These mutations greatly increase not only the risk for breast cancer in women, but also the risk for ovarian cancer in women as well as prostate and breast cancer among men. Hundreds of cancer-associated BRCA1 and BRCA2 mutations have been documented, but three specific BRCA mutations are worthy of note because they are responsible for a substantial fraction of hereditary breast cancers and ovarian cancers among women with Ashkenazi Jewish ancestry. The three mutations have also been found in individuals not known to have Ashkenazi Jewish ancestry, but such cases are rare.
Update: Two things. First, and I hope this isn’t actually necessary because you are all intelligent people who can read things and make up your own minds, but let me just state for the official record that you should never never never never NEVER take medical advice, inferred or otherwise, from celebrities or bloggers. Come on, seriously. If you’re concerned, go see a doctor.
Two: I have no idea what the $99 23andme test covers with regard to BRCA1 and BRCA2 gene mutations beyond what the company states. The most comprehensive test for BRCA1 and BRCA2 mutations was developed by a company called Myriad Genetics and costs about $3000. Myriad has patented the genes, a decision that has been sharply criticized and is currently being decided by the Supreme Court.
But many doctors, patients and scientists aren’t happy with the situation.
Some are offended by the very notion that a private company can own a patent based on a gene that was invented not by researchers in a lab but by Mother Nature. Every single cell in every single person has copies of the BRCA1 and BRCA2 genes.
Myriad officials say they deserves the patent because they invested a great deal of money to figure out the sequence and develop “synthetic molecules” based on that sequence that can be used to test the variants in a patient.
“We think it is right for a company to be able to own its discoveries, earn back its investment, and make a reasonable profit,” the company wrote on its blog.
I do know the 23andme test covers something related to the BRCA1 and BRCA2 mutations…a friend of a friend did the 23andme test, tested positive for the BRCA1 mutation, and decided to have a preventive double mastectomy after consulting her doctor and further tests. (thx, mark, allison, and ★spavis)
The quick progress of the US space program in the 1960s and 70s and the science fiction of the 70s and 80s seemed to point towards humans living permanently in space. What happened?
Ironically, our actual experiments in space living have largely reinforced this stark perspective. Real life in space is often cramped, unpleasant and even pointless. Some years back, I visited Star City near Moscow, the training centre for cosmonauts since Gagarin, where I had a chance to clamber inside a full-scale training mock-up of the Mir space station. The experience was more like residing inside a computer terminal than one of O’Neill’s cylindrical islands, so proximate and abundant were tubes, wires, levers, buttons and unnameable gadgets.
More disorienting was the placement of controls and conveniences: because space was limited, these were distributed throughout the station without reference to Earthly gravity, thus making use of ‘ceilings’ as sleeping quarters, walls for toilet cubicles and virtually any other surface for any other activity. One could get used to such things (and you’d have to be a true cynic to tire of the view outside your window). But it’s a far, far cry from strolling the wide corridors of the Starship Enterprise.
They promised us life in space, flying cars, and jetpacks but all we got were pocket-sized rectangles containing all human knowledge. FAIL.
Damn! Watch this railroad tanker car instantly implode:
I couldn’t find too much information on the source of this clip, but it appears to be part of a safety training video on the perils of improperly steam cleaning tanker cars. In the clip, the tanker car is filled with steam and the safety valves are disabled. The steam cools, then condenses, the pressure inside drops, and the pressure difference is big enough to crumple that huge railcar like a napkin.
Update: See also “sun kink”, when railroad tracks buckle in intense heat:
Normally when someone says they’ve thought up a theoretically possible perpetual motion scheme, you roll your eyes and pass the dutchie to the left hand side. But when that someone is a Nobel laureate in physics, is not generally off his rocker, and has published his idea in a prestigious peer-reviewed journal, people pay attention. Frank Wilczek believes he’s invented something called time crystals.
In February 2012, the Nobel Prize-winning physicist Frank Wilczek decided to go public with a strange and, he worried, somewhat embarrassing idea. Impossible as it seemed, Wilczek had developed an apparent proof of “time crystals” — physical structures that move in a repeating pattern, like minute hands rounding clocks, without expending energy or ever winding down. Unlike clocks or any other known objects, time crystals derive their movement not from stored energy but from a break in the symmetry of time, enabling a special form of perpetual motion.
“Most research in physics is continuations of things that have gone before,” said Wilczek, a professor at the Massachusetts Institute of Technology. This, he said, was “kind of outside the box.”
An effort to prove or disprove Wilczek’s theory is underway…let’s hope it holds up to scientific scrutiny better than Time Cube. (via digg)
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