AIDS patients are susceptible to cancers, but they usually stop taking HIV drugs before receiving cancer treatment. “That allows the virus to come back and it infects their donor cells,” Kuritzkes said.
About 34 million people are infected with HIV, the virus that causes AIDS, globally; 25 million have died from it. While there’s no vaccine, cocktails of powerful antiviral drugs called antiretroviral therapy (ART) can keep the virus suppressed and keep patients healthy. No matter how long patients take ART, however, they are never cured. The virus lurks in the body and comes back if the drugs are stopped. Scientists want to flush out these so-called reservoirs and find a way to kill the virus for good.
Brown, and now these two other men, offer some real hope.
Dr. Timothy Henrich and colleagues at Brigham and Women’s Hospital launched a search about a year ago for HIV patients with leukemia or lymphoma who had received bone marrow stem cell transplants. Bone marrow is the body’s source of immune system cells that HIV infects and it’s a likely place to look for HIV’s reservoirs.
“If you took an HIV patient getting treated for various cancers, you can check the effect on the viral reservoirs of various cancer treatments,” Kuritzkes, who works with Henrich, said. They found the two patients by asking colleagues at Dana-Farber Cancer Institute in Boston which, like Brigham and Women’s, is associated with Harvard Medical School.
Both men had endured multiple rounds of treatment for lymphoma, both had stem cell treatments and both had stayed on their HIV drugs throughout. “They went through the transplants on therapy,” Kuritzkes said.
It turns out that was key.
“We found that immediately before the transplant and after the transplant, HIV DNA was in the cells. As the patients’ cells were replaced by the donor cells, the HIV DNA disappeared,” Kuritzkes said. The donor cells, it appears, killed off and replaced the infected cells. And the HIV drugs protected the donor cells while they did it.
The two men have been HIV-free for two years and three-and-a-half years, respectively. Another man who benefited from a bone marrow transplant from a donor whose immune cells resist HIV infection has been free of HIV for five years. (via @gavinpurcell)
Yoda’s greatest display of raw power in the original trilogy came when he lifted Luke’s X-Wing from the swamp. As far as physically moving objects around goes, this was easily the biggest expenditure of energy through the Force we saw from anyone in the trilogy.
The energy it takes to lift an object to height h is equal to the object’s mass times the force of gravity times the height it’s lifted. The X-Wing scene lets us use this to put a lower limit on Yoda’s peak power output.
First we need to know how heavy the ship was. The X-Wing’s mass has never been canonically established, but its length has-16 meters. An F-22 is 19 meters long and weighs 19,700 lbs, so scaling down from this gives an estimate for the X-Wing of about 12,000 lbs (5 metric tons).
The Apollo 11 Lunar Module landed on the surface of the Moon 43 years ago today. For the 40th anniversary of the landing in 2009, I put together a page where you can watch the original CBS News coverage of Walter Cronkite reporting on the Moon landing and the first Moon walk, synced to the present-day time. I’ve updated the page to work again this year: just open this page in your browser and the coverage will start playing at the proper time. Here’s the schedule:
Moon landing broacast start: 4:10:30 pm EDT on July 20
Moon landing shown: 4:17:40 pm EDT
Moon landing broadcast end: 4:20:15 pm EDT {break}
Moon walk broadcast start: 10:51:27 pm EDT
First step on Moon: 10:56:15 pm EDT
Nixon speaks to the Eagle crew: approx 11:51:30 pm EDT
Moon walk broadcast end: 12:00:30 pm EDT on July 21
If you’ve never seen this coverage, I urge you to watch at least the landing segment (~10 min.) and the first 10-20 minutes of the Moon walk. I hope that with the old time TV display and poor YouTube quality, you get a small sense of how someone 40 years ago might have experienced it. I’ve watched the whole thing a couple of times while putting this together and I’m struck by two things: 1) how it’s almost more amazing that hundreds of millions of people watched the first Moon walk *live* on TV than it is that they got to the Moon in the first place, and 2) that pretty much the sole purpose of the Apollo 11 Moon walk was to photograph it and broadcast it live back to Earth.
Researchers led by Harvard Medical School’s John N. Kheir engineered tiny, gas-filled microparticles, which were about three micrometers in size and invisible to the naked eye. They used a device called a sonicator, which uses high-intensity sound waves, to produce a foamy liquid solution with microparticles that consist of a single layer of lipids that trap a tiny pocket of oxygen gas. They then injected the resulting mixture directly into the bloodstream of rabbits that were severely oxygen-deprived.
Within seconds, infusions of the microparticles restored the blood oxygen saturation of these mammals to near-normal levels. When the rabbits’ windpipes were completely blocked, the solution kept them alive for 15 minutes without a single breath and reduced the likelihood of cardiac arrest and organ injury.
The ideas of aerodynamics don’t apply here. Normally, air would flow around anything moving through it. But the air molecules in front of this ball don’t have time to be jostled out of the way. The ball smacks into them hard that the atoms in the air molecules actually fuse with the atoms in the ball’s surface. Each collision releases a burst of gamma rays and scattered particles.
These gamma rays and debris expand outward in a bubble centered on the pitcher’s mound. They start to tear apart the molecules in the air, ripping the electrons from the nuclei and turning the air in the stadium into an expanding bubble of incandescent plasma. The wall of this bubble approaches the batter at about the speed of light-only slightly ahead of the ball itself.
All science writing should (and probably could!) be this entertaining. (via @delfuego)
From a collection of his papers recently acquired by The Library of Congress, a 1954 reading list from physicist Carl Sagan. Huxley, Plato, Shakespeare, and the Bible are all on there among many others. If I understand mathematics properly, and I think I do, using the associative property, if you read all these books, you will become as smart and cool as Carl Sagan was. Or is it the transitive property?
Frazil ice is a Slushee-like mixture of ice and supercooled water that behaves a lot like lava or flowing cement. Here’s a short video about frazil ice in Yosemite…it starts off a bit slow but gets good around 1:30.
“We observe in our data clear signs of a new particle, at the level of 5 sigma, in the mass region around 126 GeV. The outstanding performance of the LHC and ATLAS and the huge efforts of many people have brought us to this exciting stage,” said ATLAS experiment spokesperson Fabiola Gianotti, “but a little more time is needed to prepare these results for publication.”
“The results are preliminary but the 5 sigma signal at around 125 GeV we’re seeing is dramatic. This is indeed a new particle. We know it must be a boson and it’s the heaviest boson ever found,” said CMS experiment spokesperson Joe Incandela. “The implications are very significant and it is precisely for this reason that we must be extremely diligent in all of our studies and cross-checks.”
How sure are they that they’ve found the Higgs? Brian Cox notes on Twitter:
5 sigma is the usual particle physics threshold for discovery. It roughly means that you’re 99.9999% sure
Facts change all the time. The age at which women should get a mammogram has increased. Smoking has gone from doctor recommended to deadly while the healthiness of carbs and fat seems to be in constant flux. We used to think the Earth was the center of the universe, that Pluto was a planet, and that the brontosaurus was a real dinosaur. What we know about the world is constantly changing.
Samuel Arbesman is an expert in scientometrics, literally the science of science-how we know what we know. It turns out that knowledge in most fields evolves in systematic and predictable ways, and understanding that evolution can be enormously powerful. For instance, knowing how different branches of medicine overturn their bodies of knowledge can improve the way we train (and retrain) physicians.
The Half-Life of Facts features fascinating examples from fields as diverse as technology and literature. It will help us find new ways to measure the world while accepting the limits of how much we can know with certainty.
Back in 1999, as he prepared to make a movie called The Minority Report, Steven Spielberg gathered top science and technology types to an “idea summit” where they would share thoughts on what things might look like in 50 years. To mark the ten year anniversary of the movie’s release, Wired asked a dozen of the summit attendees to reflect on the experience. According to one participant: “There was no shortage of megalomania, although there was good reason for it.”
In this series of slow motion clips, you can see that if you hold a Slinky by one end and drop it, the bottom end doesn’t actually move until the top end catches up with it.
I’ve watched this like six times and it drops my jaw every time…the bottom of the Slinky JUST. DOES. NOT. MOVE. Here’s the scientific explanation:
The explanation that “it takes time for the bottom of the slinky to feel the change” might work ok, but it isn’t the best.
Then why doesn’t the bottom of the slinky fall as the top is let go? I think the best thing is to think of the slinky as a system. When it is let get, the center of mass certainly accelerates downward (like any falling object). However, at the same time, the slinky (spring) is compressing to its relaxed length. This means that top and bottom are accelerating towards the center of mass of the slinky at the same time the center of mass is accelerating downward.
When they were launched in 1977, the two Voyager spacecraft each carried with them a 12-inch gold-plated copper record containing multimedia pertaining to life on Earth, the idea being that if an extraterrestrial ran across one of these records millions of years from now, they could play it an learn something about our planet. This site has a listing of some of the music, images, and sounds contained on the records. Here are two of the images included…the first is a rudimentary mathematics primer and the second is a family portrait:
I wonder when we’ll see these records again. I mean, it seems more plausible that Elon Musk’s grandson will mount an expedition to retrieve a Voyager probe in 2077 than some alien running across the thing.
Venus passed in front of the Sun yesterday for the last time until 2117. The transit took almost seven hours but this NASA video shows it in under a minute.
After opening, the new bridge shortly came to be known as “Galloping Gertie,” so named by white-knuckled motorists who braved the writhing bridge on windy days. Even in a light breeze, Gertie’s undulations were known to produce waves up to ten feet tall. Sometimes these occurrences were brief, and other times they lasted for hours at a time. Numerous travelers shunned the route altogether to avoid becoming seasick, whereas many thrill-seeking souls paid the 75-cent toll to traverse Gertie during her more spirited episodes.
According to a recent study, the cause of Pine Mouth (where eating pine nuts can make food taste horrible for days afterwards) is still unknown. The full text of the study is behind a paywall but The Awl has a short summary of the findings.
Now, a new publication by the Journal of Agricultural & Food Chemistry finds esteemed scientists literally throwing up their hands. They learned a lot about pine nuts and their composition! But nothing useful.
In June 2007 Jenny McCarthy began promoting anti-vaccination rhetoric. Because of her celebrity status she has appeared on several television shows and has published multiple books advising parents not to vaccinate their children. This has led to an increase in the number of vaccine preventable illnesses as well as an increase in the number of vaccine preventable deaths.
Indigo children is a term used to describe children who are believed to possess special, unusual and sometimes supernatural traits or abilities. The term is pseudoscientific. The idea is based on New Age concepts developed in the 1970s by Nancy Ann Tappe and further developed by Jan Tober and Lee Carroll. The concept of indigo children gained popular interest with the publication of a series of books in the late 1990s and the release of several films in the following decade. A variety of books, conferences and related materials have been created surrounding belief in the idea of indigo children and their nature and abilities. The interpretations of these beliefs range from their being the next stage in human evolution, in some cases possessing paranormal abilities such as telepathy, to the belief that they are more empathic and creative than their peers.
I missed this last July when the news came out, but since I’ve been following the Pioneer Anomaly for the past eight years, I wanted to mention it here for closure purposes. First, what the hell is the Pioneer Anomaly?
The Pioneer anomaly or Pioneer effect is the observed deviation from predicted accelerations of the Pioneer 10 and Pioneer 11 spacecraft after they passed about 20 astronomical units (3×10^9 km; 2×10^9 mi) on their trajectories out of the Solar System. Both Pioneer spacecraft are escaping the Solar System, but are slowing under the influence of the Sun’s gravity. Upon very close examination of navigational data, the spacecraft were found to be slowing slightly more than expected. The effect is an extremely small but unexplained acceleration towards the Sun, of 8.74±1.33x10^-10 m/s^2.
For their new analysis, Turyshev et. al. compiled a lot more data than had ever been analyzed before, spanning a much longer period of the Pioneers’ flight times. They studied 23 years of data from Pioneer 10 instead of just 11, and 11 years of data from Pioneer 11 instead of 3. As explained in their new paper, the more complete data sets reveal that the spacecraft’s anomalous acceleration did indeed seem to decrease with time. In short, the undying force had been dying after all, just like the decaying plutonium.
A more recent paper by the same researchers offers even more support for their theory. Case closed, I say.
Mustafa invented a way of tapping this quantum effect via what’s known as the dynamic Casimir effect. This uses a “moving mirror” cavity, where two very reflective very flat plates are held close together, and then moved slightly to interact with the quantum particle sea. It’s horribly technical, but the end result is that Mustafa’s use of shaped silicon plates similar to those used in solar power cells results in a net force being delivered. A force, of course, means a push or a pull and in space this equates to a drive or engine.
To what degree would nuclear research become shackled by the requirements of national security? Would the open circulation of new scientific knowledge cease if that knowledge was relevant to nuclear fission? Those questions were hardly idle speculation: From the fall of 1945 through the summer of 1946, the US Congress was crafting new, unprecedented legislation that would legally define the bounds of open scientific research and even free speech. The idea of restricting open scientific communication “may seem drastic and far-reaching,” President Harry S. Truman argued in an October 1945 statement exhorting Congress to rapid action. But, he said, the atomic bomb “involves forces of nature too dangerous to fit into any of our usual concepts.”
The former Manhattan Project scientists who founded what would eventually become the Federation of American Scientists were adamantly opposed to keeping nuclear technology a closed field. From early on they argued that there was, as they put it, “no secret to be kept.” Attempting to control the spread of nuclear weapons by controlling scientific information would be fruitless: Soviet scientists were just as capable as US scientists when it came to discovering the truths of the physical world. The best that secrecy could hope to do would be to slightly impede the work of another nuclear power. Whatever time was bought by such impediment, they argued, would come at a steep price in US scientific productivity, because science required open lines of communication to flourish.
At the University of Pennsylvania were nine scientists sympathetic to that message. All had been involved with wartime work, but in the area of radar, not the bomb. Because they had not been part of the Manhattan Project in any way, they were under no legal obligation to maintain secrecy; they were simply informed private citizens. In the fall of 1945, they tried to figure out the technical details behind the bomb.
As a naturalist, da Vinci probed, prodded, and tested his way to a deeper understanding of how organisms work and why, often dissecting his object of study with this aim. “I thought, why not present the idea of data analysis to the world within the naturalist world of Leonardo?” Cittolin says. In the drawing below, the CMS detector is the organism to be opened; the particles passing through it and the tracks they leave behind are organs exposed for further investigation.
Cittolin brings a sense of humor to his work. For example, after betting CMS colleague Ariella Cattai that he could produce a quality drawing for the cover of the CMS tracker technical proposal by a given deadline, he included in the drawing a secret message in mirror-image writing-which was also a favorite of da Vinci’s. The message jokingly demanded a particular reward for his hard work. The completed picture was delivered on time and within a few hours Cattai cleverly spotted and deciphered the message. She promptly presented him with the requested bottle of wine.
The Democrat and Chronicle learned of the facility when an employee happened to mention it to a reporter a few months ago.
The recent silence was by design. Detailed information about nuclear power plants and other entities with radioactive material has been restricted since the 2001 terrorist attacks.
Nuclear non-proliferation experts express surprise that an industrial manufacturer like Eastman Kodak had had weapons-grade uranium, especially in a post-9/11 world.
“I’ve never heard of it at Kodak,” said Miles Pomper, senior research associate at the Center for Nonproliferation Studies in Washington. “It’s such an odd situation because private companies just don’t have this material.”
In studying yogurt’s effects on obesity in mice, a team of MIT scientists discovered several unanticipated results. Basically, yogurt turned these mice into Kanye. Science is weird.
First, the scientists noticed that the yogurt-eating mice were incredibly shiny. Using both traditional histology techniques and cosmetic rating scales, the researchers showed that these animals had 10 times the active follicle density of other mice, resulting in luxuriantly silky fur.
Then the researchers spotted something particular about the males: they projected their testes outward, which endowed them with a certain “mouse swagger,” Erdman says. On measuring the males, they found that the testicles of the yogurt consumers were about 5 percent heavier than those of mice fed typical diets alone and around 15 percent heavier than those of junk-eating males.
More important, that masculinity pays off. In mating experiments, yogurt-eating males inseminated their partners faster and produced more offspring than control mice. Conversely, females that ate the yogurt diets gave birth to larger litters and weaned those pups with greater success. Reflecting on their unpublished results, Erdman and Alm think that the probiotic microbes in the yogurt help to make the animals leaner and healthier, which indirectly improves sexual machismo.
In the episode “The Kingsroad,” we learn that Westeros has at least one moon. It’s very possible, therefore, that they have a very small or distant moon, that is causing a variable tilt in their planet’s rotational axis.
It’s interesting to note that, according to legend, Westeros used to have two moons, but “one wandered too close to the sun and it cracked from the heat” pouring out a thousand thousand dragons. Well, dragons aside, it’s conceivable that some kind of cataclysmic celestial event could have wiped out their second moon, which would have thrown their planet’s rotational axis out of whack.
In a review of the Color Uncovered iPad app, Carl Zimmer highlights something I hadn’t heard before: Claude Monet could see in ultraviolet.
Late in his life, Claude Monet developed cataracts. As his lenses degraded, they blocked parts of the visible spectrum, and the colors he perceived grew muddy. Monet’s cataracts left him struggling to paint; he complained to friends that he felt as if he saw everything in a fog. After years of failed treatments, he agreed at age 82 to have the lens of his left eye completely removed. Light could now stream through the opening unimpeded. Monet could now see familiar colors again. And he could also see colors he had never seen before. Monet began to see — and to paint — in ultraviolet.
Octopuses have the largest brains of any invertebrate. Athena’s is the size of a walnut — as big as the brain of the famous African gray parrot, Alex, who learned to use more than one hundred spoken words meaningfully. That’s proportionally bigger than the brains of most of the largest dinosaurs.
Another measure of intelligence: you can count neurons. The common octopus has about 130 million of them in its brain. A human has 100 billion. But this is where things get weird. Three-fifths of an octopus’s neurons are not in the brain; they’re in its arms.
“It is as if each arm has a mind of its own,” says Peter Godfrey-Smith, a diver, professor of philosophy at the Graduate Center of the City University of New York, and an admirer of octopuses. For example, researchers who cut off an octopus’s arm (which the octopus can regrow) discovered that not only does the arm crawl away on its own, but if the arm meets a food item, it seizes it — and tries to pass it to where the mouth would be if the arm were still connected to its body.
“Meeting an octopus,” writes Godfrey-Smith, “is like meeting an intelligent alien.” Their intelligence sometimes even involves changing colors and shapes. One video online shows a mimic octopus alternately morphing into a flatfish, several sea snakes, and a lionfish by changing color, altering the texture of its skin, and shifting the position of its body. Another video shows an octopus materializing from a clump of algae. Its skin exactly matches the algae from which it seems to bloom-until it swims away.
The Dyson sphere, also referred to as a Dyson shell, is the brainchild of the physicist and astronomer Freeman Dyson. In 1959 he put out a two page paper titled, “Search for Artificial Stellar Sources of Infrared Radiation” in which he described a way for an advanced civilization to utilize all of the energy radiated by their sun. This hypothetical megastructure, as envisaged by Dyson, would be the size of a planetary orbit and consist of a shell of solar collectors (or habitats) around the star. With this model, all (or at least a significant amount) of the energy would hit a receiving surface where it can be used. He speculated that such structures would be the logical consequence of the long-term survival and escalating energy needs of a technological civilization.
Needless to say, the amount of energy that could be extracted in this way is mind-boggling. According to Anders Sandberg, an expert on exploratory engineering, a Dyson sphere in our solar system with a radius of one AU would have a surface area of at least 2.72x1017 km2, which is around 600 million times the surface area of the Earth. The sun has an energy output of around 4x1026 W, of which most would be available to do useful work.
The downside: we’d have to part with Mercury to do it.
And yes, you read that right: we’re going to have to mine materials from Mercury. Actually, we’ll likely have to take the whole planet apart. The Dyson sphere will require a horrendous amount of material-so much so, in fact, that, should we want to completely envelope the sun, we are going to have to disassemble not just Mercury, but Venus, some of the outer planets, and any nearby asteroids as well.
At Forbes, Alex Knapp explains why Dvorsky’s scheme and timeline might not work.
I emailed Astronomer Phil Plait about this project, who told me in no uncertain terms that the project doesn’t make sense.
“Dismantling Mercury, just to start, will take 2 x 10^30 Joules, or an amount of energy 100 billion times the US annual energy consumption,” he said. “[Dvorsky] kinda glosses over that point. And how long until his solar collectors gather that much energy back, and we’re in the black?”
Now available in its entirety on YouTube, a 95-minute documentary on physicist Richard Feynman called No Ordinary Genius.
The excellent film on Andrew Wiles’ search for the solution to Fermat’s Last Theorem is available as well (watch the first two minutes and you’ll be hooked).
A pair of recent info visualizations look as though they were painted by Vincent van Gogh. Wind Map shows the realtime flow of wind over the United States.
Perpetual Ocean is a NASA animation of ocean currents around the world.
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